Research

Our research currently offers a delightful 3-course, theme-focused scientific menu from our talented investigators.
Please feel free to explore our research topics below.

Prix Fixe

SNX27 and the retromer complex
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SNX27 is a PDZ-domain member of the sorting nexin family of endosomal trafficking components, and a member of the retromer complex.

Our previous studies indicate that SNX27 can enhance endosome to cell surface recycling of SORLA, and inhibit gamma-secretase dependent APP cleavage, both of which reduce Abeta generation, more here (opens in new tab).

​We are in the process of characterizing other SNX27 targets that may be relevant to AD.

"A versatile complement to any complex meal, SNX27 offers distinct notes of nutmeg and olive oil. Often served with VPS35, VPS26 and VPS29 on a bed of PIP3, SNX27 is best enjoyed tubulated towards a herb-infused foam bilayer."

Exploring neuroprotective roles for SORLA in neurons and microglia
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SORLA is a transmembrane trafficking component which can associate with the SNX27/retromer complex.

SORLA polymorphisms have also been associated with increased AD risk. We are exploring why SORLA dysregulation might affect AD onset in neurons and microglia, more here (opens in new tab).

"SORLA is a rare, classical ingredient as a counterpoint to bitter Abeta nuggets. SORLA offers a variety of fruity and savory notes to synaptic function and brightness to hand-chopped neurons."

Trème Fraîche: The microglial TREM2 immune receptor and AD

TREM2 is a microglial immune receptor we have shown to bind and mediate microglial activation in response to Abeta.

Mutations in TREM2 (R47H) have been associated with significantly increased risk of AD onset. We are currently investigating potential mechanisms underlying TREM R47H and TREM2-associated AD pathogenesis.

"Creamy TREM2 variants in a rich, warmed roasted marrow parsley butter and nutty Abeta nuggets on toasted baguette slices. Served with chilled cervelle de veau braised in aged citrus bouillion and ponzu jelly."

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à la carte

We are also interested in proteostasis, protein misfolding and neurodegeneration. We are currently investigating how UPR components such as ATF6 potentially relate to AD, as well as potential relationships between the ERAD complex and the newly-described ERAD component membralin in neurodegeneration.