Research Publications
Fresh and made to order, lightly salted and served chilled.
2020-present
Michael L. van de Weijer, Krishna Samanta, Nikita Sergejevs, LuLin Jiang, Maria Emilia Dueñas, Tiaan Heunis, Timothy Y. Huang, Randal J. Kaufman, Matthias Trost, Sumana Sanyal, Sally A. Cowley & Pedro Carvalho. Tapasin assembly surveillance by the RNF185/Membralin ubiquitin ligase complex regulates MHC-I surface expression. Nat Commun 15: 8508, 2024. PMID: 39353943
(congrats Dr. Carvalho and team!)
Denghong Zhang*, Wei Zhang*, Chen Ming*, Xuheng Gao*, Huilong Yuan, Xinru Mao, Xiaojie Lin, Chunping Wang, Xiaoyi Guo, Ying Du, Lin Shao, Renzhi Yang, Zhihao Lin, Xilin Wu, Timothy Y. Huang, Zhanxiang Wang, Yun-wu Zhang, Huaxi Xu, Yingjun Zhao. P-tau217 correlates with neurodegeneration in Alzheimer's disease and targeting p-tau217 with immunotherapy ameliorates murine tauopathy. Neuron 12: 1676-1693, 2024, PMID: 38513667. *equal contribution
Qiuyan Cui, Shiqi Liang, Hao Li, Yiqing Guo, Junkai Lv, Xinyuan Wang Pengwei Qin, Huaxi Xu, Timothy Y. Huang, Youming Lu, Qing Tian, Tongmei Zhang. SNX17 Mediates Dendritic Spine Maturation via p140Cap. Mol Neurobiol, 61: 1346-1362, 2024. PMID: 37704928
Stella Victorelli,* Hanna Salmonowicz,*, James Chapman*, Helene Martini, Maria Grazia Vizioli, Joel S. Riley, Catherine Cloix, Ella Hall-Younger, Jair Machado Espindola-Netto, Diana Jurk, Anthony B. Lagnado, Lilian Sales Gomez, Joshua N. Farr, Dominik Saul, Rebecca Reed, George Kelly, Madeline Eppard, Laura C. Greaves, Zhixun Dou, Nicholas Pirius, Karolina Szczepanowska, Rebecca A. Porritt, Huijie Huang, Timothy Y. Huang, Derek A Mann, Claudio Akio Masuda, Sundeep Khosla, Haiming Dai, Scott H Kaufmann, Emmanouil Zacharioudakis, Evripidis Gavathiotis, Nathan LeBrasseur, Xue Lei, Alva G. Sainz, Viktor I. Korolchuk, Peter D. Adams, Gerald S. Shadel, Stephen W.G. Tait, João F. Passos. Apoptotic stress causes mtDNA release during senescence and drives the SASP. Nature 622(7983): 627–636, 2023. PMID: 37821702
Yini Zhao, Qiuyang Zheng, Yujuan Hong, Yue Gao, Jiaojiao Hu, Maoju Lang, Hongfeng Zhang,, Ying Zhou, Hong Luo, Xian Zhang, Hao Sun, Xiao-Xin Yan, Timothy Y. Huang, Yan-Jiang Wang, Huaxi Xu, Cong Liu, Xin Wang. Neutralization of pathogenic B2M-Aβ aggregates ameliorates amyloid pathology and Alzheimer’s disease-associated cognitive deficits. Nat Neurosci, 2023 (https://doi.org/10.1038/s41593-023-01352-1). PMID: 37264159
Yue Gao,Yujuan Hong, Lihong Huang, Shuang Zheng, Haibin Zhang, Shihua Wang, Yi Yao, Yini Zhao, Lin Zhu, Qiang Xu, Xuhui Chai, Yuanyuan Zeng, Yuzhe Zeng, Liangkai Zheng, Yulin Zhou, Hong Luo, Xian Zhang, Hongfeng Zhang, Ying Zhou, Guo Fu, Hao Sun, Jiahuai Han, Timothy Y. Huang, Qiuyang Zheng, Huaxi Xu, Xin Wang. β2-microglobulin functions as an endogenous NMDAR antagonist to impair synaptic function. Cell 186: 1026-1038, 2023
(CONGRATS, Xin and team!)
Bing Zhu(1), Yan Liu(1), Spring Hwang, Kailey Archuleta, Huijie Huang, Alex Campos, Rabi Murad, Juan Piña-Crespo, Huaxi Xu*, Timothy Y. Huang*. Trem2 deletion enhances tau dispersion and pathology through microglia exosomes. Mol Neurodeg 17:58, 2022. (1), equal contributions; *corresponding author. PMID: 36056435, PMCID: PMC9438095,
Peng Zhao, Yuanzhong Xu, Lu‑Lin Jiang, Xuejun Fan, Zhiqiang Ku, Leike Li, Xiaoye Liu, Mi Deng, Hisashi Arase, Jay‑Jiguang Zhu, Timothy Y. Huang, Yingjun Zhao, Chengcheng Zhang, Huaxi Xu, Qingchun Tong, Ningyan Zhang and Zhiqiang An. LILRB2‑mediated TREM2 signaling inhibition suppresses microglia functions. Mol Neurodeg 17:44, 2022.
Qiuyang Zheng, Guilin Li, Beibei Song, Fang Cai, Meiling Wu, Yingjun Zhao, Lulin Jiang, Tiantian Guo, Mingyu Shen, Ying Zhou, Yini Zhao, Anjie Di, Lishan Zhang, Xiufang Zhang, Hong Luo, Xian Zhang, Timothy Huang, Chen Dong, Huaxi Xu, Weihong Song, and Xin Wang. USP25 deficiency ameliorates amyloid pathology through regulating APP processing and Aβ generation. J Clin Invest 132(5):e152170, 2022
Peng Xu, Jerry Chang, Xiaopu Zhou, Wei Wang, Michael Bamkole, Eitan Wong, Karima Bettayeb, Lu-Lin Jiang, Timothy Huang, Wenjie Luo, Huaxi Xu, Angus Nairn, Marc Flajolet, Nancy Ip, Yueming Li, and Paul Greengard. GSAP regulates lipid homeostasis and mitochondrial function associated with Alzheimer's disease. J Exp Med 218: e20202446, 2021. PMID: 34156424, PMCID: PMC8222926.
Dongdong Zhao, Yunqiang Zhou, Yuanhui Huo, Jian Meng, Xiaoxia Xiao, Linkun Han, Xian Zhang, Hong Luo, Dan Can, Hao Sun, Timothy Huang, Xin Wang, Jie Zhang, Fa-rong Liu, Huaxi Xu and Yun-wu Zhang, . RPS23RG1 modulates tau phosphorylation and axon outgrowth through regulating p35 proteasomal degradation. Cell Death Differ 28: 337-348, 2021.
Tongfei Liu (1), Bing Zhu (1), Yan Liu (1), Xiaoming Zhang (1), Jun Yin (1), Xiaoguang Li, LuLin Jiang, Andrew P. Hodges, Sara Brin Rosenthal, Lisa Zhou, Joel Yancey, Amanda McQuade, Mathew Blurton-Jones, Rudolph E. Tanzi, Timothy Y. Huang*, and Huaxi Xu*. Multi-omic comparison of Alzheimer’s variants in human ESC-derived microglia reveals convergence at APOE. J Exp Med, 217(12): e20200474, 2020.
*Corresponding author, (1) equal contributions.
Jessica Stupack, Xiao-Peng Xiong, Lu-Lin Jiang, Tongmei Zhang, Lisa Zhou, Alex Campos, Barbara Ranscht, William Mobley, Elena B. Pasquale, Huaxi Xu*, Timothy Y. Huang*. Soluble SORLA enhances neurite outgrowth and regeneration through activation of the EGF Receptor/ERK signaling axis. J Neuroscience 40:5908-5921, 2020. (Cover article, featured article). *Corresponding author.
(congrats Dr. Carvalho and team!)
Denghong Zhang*, Wei Zhang*, Chen Ming*, Xuheng Gao*, Huilong Yuan, Xinru Mao, Xiaojie Lin, Chunping Wang, Xiaoyi Guo, Ying Du, Lin Shao, Renzhi Yang, Zhihao Lin, Xilin Wu, Timothy Y. Huang, Zhanxiang Wang, Yun-wu Zhang, Huaxi Xu, Yingjun Zhao. P-tau217 correlates with neurodegeneration in Alzheimer's disease and targeting p-tau217 with immunotherapy ameliorates murine tauopathy. Neuron 12: 1676-1693, 2024, PMID: 38513667. *equal contribution
Qiuyan Cui, Shiqi Liang, Hao Li, Yiqing Guo, Junkai Lv, Xinyuan Wang Pengwei Qin, Huaxi Xu, Timothy Y. Huang, Youming Lu, Qing Tian, Tongmei Zhang. SNX17 Mediates Dendritic Spine Maturation via p140Cap. Mol Neurobiol, 61: 1346-1362, 2024. PMID: 37704928
Stella Victorelli,* Hanna Salmonowicz,*, James Chapman*, Helene Martini, Maria Grazia Vizioli, Joel S. Riley, Catherine Cloix, Ella Hall-Younger, Jair Machado Espindola-Netto, Diana Jurk, Anthony B. Lagnado, Lilian Sales Gomez, Joshua N. Farr, Dominik Saul, Rebecca Reed, George Kelly, Madeline Eppard, Laura C. Greaves, Zhixun Dou, Nicholas Pirius, Karolina Szczepanowska, Rebecca A. Porritt, Huijie Huang, Timothy Y. Huang, Derek A Mann, Claudio Akio Masuda, Sundeep Khosla, Haiming Dai, Scott H Kaufmann, Emmanouil Zacharioudakis, Evripidis Gavathiotis, Nathan LeBrasseur, Xue Lei, Alva G. Sainz, Viktor I. Korolchuk, Peter D. Adams, Gerald S. Shadel, Stephen W.G. Tait, João F. Passos. Apoptotic stress causes mtDNA release during senescence and drives the SASP. Nature 622(7983): 627–636, 2023. PMID: 37821702
Yini Zhao, Qiuyang Zheng, Yujuan Hong, Yue Gao, Jiaojiao Hu, Maoju Lang, Hongfeng Zhang,, Ying Zhou, Hong Luo, Xian Zhang, Hao Sun, Xiao-Xin Yan, Timothy Y. Huang, Yan-Jiang Wang, Huaxi Xu, Cong Liu, Xin Wang. Neutralization of pathogenic B2M-Aβ aggregates ameliorates amyloid pathology and Alzheimer’s disease-associated cognitive deficits. Nat Neurosci, 2023 (https://doi.org/10.1038/s41593-023-01352-1). PMID: 37264159
Yue Gao,Yujuan Hong, Lihong Huang, Shuang Zheng, Haibin Zhang, Shihua Wang, Yi Yao, Yini Zhao, Lin Zhu, Qiang Xu, Xuhui Chai, Yuanyuan Zeng, Yuzhe Zeng, Liangkai Zheng, Yulin Zhou, Hong Luo, Xian Zhang, Hongfeng Zhang, Ying Zhou, Guo Fu, Hao Sun, Jiahuai Han, Timothy Y. Huang, Qiuyang Zheng, Huaxi Xu, Xin Wang. β2-microglobulin functions as an endogenous NMDAR antagonist to impair synaptic function. Cell 186: 1026-1038, 2023
(CONGRATS, Xin and team!)
Bing Zhu(1), Yan Liu(1), Spring Hwang, Kailey Archuleta, Huijie Huang, Alex Campos, Rabi Murad, Juan Piña-Crespo, Huaxi Xu*, Timothy Y. Huang*. Trem2 deletion enhances tau dispersion and pathology through microglia exosomes. Mol Neurodeg 17:58, 2022. (1), equal contributions; *corresponding author. PMID: 36056435, PMCID: PMC9438095,
Peng Zhao, Yuanzhong Xu, Lu‑Lin Jiang, Xuejun Fan, Zhiqiang Ku, Leike Li, Xiaoye Liu, Mi Deng, Hisashi Arase, Jay‑Jiguang Zhu, Timothy Y. Huang, Yingjun Zhao, Chengcheng Zhang, Huaxi Xu, Qingchun Tong, Ningyan Zhang and Zhiqiang An. LILRB2‑mediated TREM2 signaling inhibition suppresses microglia functions. Mol Neurodeg 17:44, 2022.
Qiuyang Zheng, Guilin Li, Beibei Song, Fang Cai, Meiling Wu, Yingjun Zhao, Lulin Jiang, Tiantian Guo, Mingyu Shen, Ying Zhou, Yini Zhao, Anjie Di, Lishan Zhang, Xiufang Zhang, Hong Luo, Xian Zhang, Timothy Huang, Chen Dong, Huaxi Xu, Weihong Song, and Xin Wang. USP25 deficiency ameliorates amyloid pathology through regulating APP processing and Aβ generation. J Clin Invest 132(5):e152170, 2022
Peng Xu, Jerry Chang, Xiaopu Zhou, Wei Wang, Michael Bamkole, Eitan Wong, Karima Bettayeb, Lu-Lin Jiang, Timothy Huang, Wenjie Luo, Huaxi Xu, Angus Nairn, Marc Flajolet, Nancy Ip, Yueming Li, and Paul Greengard. GSAP regulates lipid homeostasis and mitochondrial function associated with Alzheimer's disease. J Exp Med 218: e20202446, 2021. PMID: 34156424, PMCID: PMC8222926.
Dongdong Zhao, Yunqiang Zhou, Yuanhui Huo, Jian Meng, Xiaoxia Xiao, Linkun Han, Xian Zhang, Hong Luo, Dan Can, Hao Sun, Timothy Huang, Xin Wang, Jie Zhang, Fa-rong Liu, Huaxi Xu and Yun-wu Zhang, . RPS23RG1 modulates tau phosphorylation and axon outgrowth through regulating p35 proteasomal degradation. Cell Death Differ 28: 337-348, 2021.
Tongfei Liu (1), Bing Zhu (1), Yan Liu (1), Xiaoming Zhang (1), Jun Yin (1), Xiaoguang Li, LuLin Jiang, Andrew P. Hodges, Sara Brin Rosenthal, Lisa Zhou, Joel Yancey, Amanda McQuade, Mathew Blurton-Jones, Rudolph E. Tanzi, Timothy Y. Huang*, and Huaxi Xu*. Multi-omic comparison of Alzheimer’s variants in human ESC-derived microglia reveals convergence at APOE. J Exp Med, 217(12): e20200474, 2020.
*Corresponding author, (1) equal contributions.
Jessica Stupack, Xiao-Peng Xiong, Lu-Lin Jiang, Tongmei Zhang, Lisa Zhou, Alex Campos, Barbara Ranscht, William Mobley, Elena B. Pasquale, Huaxi Xu*, Timothy Y. Huang*. Soluble SORLA enhances neurite outgrowth and regeneration through activation of the EGF Receptor/ERK signaling axis. J Neuroscience 40:5908-5921, 2020. (Cover article, featured article). *Corresponding author.
2015-2019
Fanwei Zeng, Xuehai Ma, Lin Zhu, Qiang Xu, Yuzhe Zeng, Yue Gao, Guilin Li,, Tiantian Guo, Haibin Zhang, Xiaoyan Tang, Ziqiang Wang, Zesen Ye, Liangkai Zheng, Hongfeng Zhang, Qiuyang Zheng, Kunping Li, Jinfang Lu, Xueting Qi, Hong Luo, Xian Zhang, Zhanxiang Wang, Yulin Zhou, Yi Yao, Rongqin Ke, Ying Zhou, Yan Liu, Hao Sun, Timothy Huang, Zhicheng Shao, Huaxi Xu, and Xin Wang. The deubiquitinase USP6 affects memory and synaptic plasticity in an NMDA receptor-dependent manner. PLoS Biol 17: e3000525, 2019.
Yongzhuang Xie, Mengxi Niu, Chengxiang Ji, Timothy Y Huang, Cuilin Zhang, Ye Tian, Zhun Shi, Chen Wang, Yingjun Zhao, Hong Luo, Dan Can, Huaxi Xu, Yun-wu Zhang, Xian Zhang. SNX8 Enhances Non-Amyloidogenic APP Trafficking and Attenuates Aβ Accumulation and Memory Deficits in an AD Mouse. Front Cell Neurosci 13: 410, 2019.
Cuilin Zhang, Yongzhuang Xie, Zhenqiu Tan, Yingjun Zhao, Timothy Y Huang, Zhaoping Lu, Hong Luo, Dan Can, Huaxi Xu, Yun-wu Zhang, Xian Zhang. Appoptosin Mediates Lesions Induced by Oxidative Stress Through the JNK-FoxO1 Pathway. Front Aging Neurosci 11: 243, 2019.
Jiechao Zhou, Hei-Man Chow, Yan Liu, Di Wu, Meng Shi, Jieyin Li, Lei Wen，Yuehong Gao, Guimiao Chen, Kai Zhuang, Hui Lin, Guanyun Zhang, Wenting Xie, Huifang Li, Lige Leng, Mengdan Wang, Naizhen Zheng, Hao Sun, Yingjun Zhao, Yunwu Zhang, Maoqiang Xue, Timothy Y. Huang, Guojun Bu, Huaxi Xu, Zengqiang Yuan, Karl Herrup, Jie Zhang. CDK5-dependent BAG3 degradation modulates synaptic protein turnover in Alzheimer’s disease. Biol Psych 87: 756-769, 2019.
Lu-Lin Jiang, Bing Zhu, Yingjun Zhao, Xiaoguang Li, Tongfei Liu, Juan Pina-Crespo, Lisa Zhou, Wenxi Xu, Maria J Rodriguez, Haiyang Yu, Don W. Cleveland, John Ravits, Sandrine Da Cruz, Tao Long, Timothy Y. Huang, Huaxi Xu. Membralin deficiency dysregulates astrocytic glutamate homeostasis leading to ALS-like impairment. J Clin Invest 129: 3103-3120, 2019. PMID: 31112137, PMCID: PMC6668683.
Lige Leng, Kai Zhuang, Zeyue Liu, Changquan Huang, Yuehong Gao, Guimiao Chen, Hui Lin, Yu Hu, Di Wu, Meng Shi, Wenting Xie, Hao Sun, Zhicheng Shao, Huifang Li, Kunkun Zhang, Wei Mo, Timothy Y. Huang, Maoqiang Xue, Zengqiang Yuan, Xia Zhang, Guojun Bu, Huaxi Xu, Qi Xu, Jie Zhang. Menin deficiency leads to depressive-like behavior in mice by modulating astrocyte-mediated neuroinflammation. Neuron 100: 551-563, 2018. PMID: 30220511
Dongdong Zhao, Jian Meng, Yingjun Zhao, Yuanhui Huo, Yan Liu, Naizhen Zheng, Muxian Zhang, Yue Gao, Zhicai Chen, Hao Sun, Xiangyu Wang, Chuya Jing, Tongmei Zhang, Xian Zhang, Hong Luo, Xin Wang, Jie Zhang, Fa-rong Liu, Yanfang Li, Guojun Bu, Lei Wen, Timothy Y. Huang, Huaxi Xu, Yun-wu Zhang. RPS23RG1 is Required for Synaptic Integrity and Rescues Alzheimer’s Associated Cognitive Deficits. Biol Psych S0006-3223(18)31782-7, 2018. PMID: 30292394, PMCID: PMC6389446
Kai Zhuang, Changquan Huang, Lige Leng, Honghua Zheng, Yuehong Gao, Guimiao Chen, Zhilin Ji, Hao Sun, Yu Hu, Di Wu, Meng Shi, Huifang Li, Yingjun Zhao, Yunwu Zhang, Maoqiang Xue, Guojun Bu, Timothy Y. Huang, Huaxi Xu, and Jie Zhang. Neuron-Specific Menin Deletion Leads to Synaptic Dysfunction and Cognitive Impairment by Modulating p35 Expression. Cell Rep 24: 701-712, 2018. PMID: 30021166
Ying Du,Yingjun Zhao, Chuan Li, Qiuyang Zheng, Jing Tian, Zhuyi Li, Timothy Y. Huang, Wei Zhang, Huaxi Xu. Inhibition of PKCδ reduces amyloid-beta levels and reverses Alzheimer Disease phenotypes. J Exp Med 215: 1665-1677, 2018. PMID: 29739836
Yingjun Zhao, Xilin Wu, Xiaoguang Li, Lu-Lin Jiang, Xun Gui, Yan Liu, Yu Sun, Bing Zhu, Juan C. Piña-Crespo, Ningyan Zhang, Xiaochun Chen, Guojun Bu, Zhiqiang An, Timothy Y. Huang and Huaxi Xu. TREM2 is a receptor for β-amyloid and mediates microglial response to β-amyloid. Neuron 97: 1023-1031, 2018. PMID: 29518356
Bing Zhu, LuLin Jiang, Timothy Huang, Yingjun Zhao, Tongfei Liu, Yongwang Zhong, Xiaoguang Li, Alexandre Campos, Kenneth Pomeroy, Eliezer Masliah, Dongxian Zhang and Huaxi Xu. ER-associated degradation regulates Alzheimer’s amyloid pathology and memory function by modulating γ-secretase activity. Nat Commun 8: 1472, 2017. PMID: 29133892
Timothy Y. Huang*, Yingjun Zhao*, Lu-lin Jiang, Xiaoguang Li, Yan Liu, Yu Sun, Juan Pina-Crespo, Bing Zhu, Eliezer Masliah, Thomas E. Willnow, Elena B. Pasquale, Huaxi Xu. SORLA attenuates EphA4 signaling and inhibits β-amyloid-induced neurodegeneration. J Exp Med 214: 3669-3685, 2017. PMID: 29114064, PMCID: PMC5716044.
Yingjun Zhao, Xiaoguang Li, Timothy Huang, Muxian Zhang, Xin Wang, Yun-wu Zhang, Guojun Bu, Qi Wang, and Huaxi Xu. Intracellular trafficking of triggering receptor expressed on myeloid cells 2 (TREM2) is regulated by presenilin 1. Experimental & Molecular Medicine, 49: e405, 2017 PMID: 29611543.
Xin Wang, Ying Zhou, Jian Wang, I-Chu Tseng, Timothy Huang, Yingjun Zhao, Qiuyang Zheng, Yue Gao, Hong Luo, Xian Zhang, Guojun Bu, Wanjin Hong, and Huaxi Xu. SNX27 Deletion Causes Hydrocephalus through Impairing Ependymal Cell Differentiation and Ciliogenesis. J. Neurosci 36: 12586-12597, 2016. PMID: 27974614 , PMCID: PMC5157104
Timothy Y. Huang, Yingjun Zhao, Xiaoguang Li, Xin Wang, I-Chu Tseng, Robert Thompson, Shichun Tu, Thomas E. Willnow, Yun-wu Zhang, Huaxi Xu. SNX27 and SORLA interact to reduce amyloidogenic subcellular distribution and processing of amyloid precursor protein (APP). J Neurosci 36: 7996-8011, 2016. PMID: 27466343, PMCID: PMC4961782
Li Yan, Yaomin Chen, Wubo Li, Xiumei Huang, Hedieh Badie, Fan Jian, Timothy Huang, Yingjun Zhao, Stanley N. Cohen, Limin Li, Yun-wu Zhang, Huanmin Luo, Shichun Tu & Huaxi Xu. RPS23RG1 reduces Aβ oligomer induced synaptic and cognitive deficits. Sci Rep 6: 18668, 2016. PMCID: PMC4702092
Yingjun Zhao, I-Chu Tseng, Charles J. Heyser, Edward Rockenstein, Michael Mante, Anthony Adame, Qiuyang Zheng, Timothy Huang, Xin Wang, Pharhad E. Arslan, Paramita Chakrabarty, Chengbiao Wu, Guojun Bu, William C. Mobley, Yun-wu Zhang, Peter St. George-Hyslop, Eliezer Masliah, Paul Fraser, Huaxi Xu. Appoptosin-Mediated Caspase Cleavage of Tau Contributes to Progressive Supranuclear Palsy Pathogenesis. Neuron 87: 963-975, 2015. PMID: 26335643, PMCID: PMC4575284
Yongzhuang Xie, Mengxi Niu, Chengxiang Ji, Timothy Y Huang, Cuilin Zhang, Ye Tian, Zhun Shi, Chen Wang, Yingjun Zhao, Hong Luo, Dan Can, Huaxi Xu, Yun-wu Zhang, Xian Zhang. SNX8 Enhances Non-Amyloidogenic APP Trafficking and Attenuates Aβ Accumulation and Memory Deficits in an AD Mouse. Front Cell Neurosci 13: 410, 2019.
Cuilin Zhang, Yongzhuang Xie, Zhenqiu Tan, Yingjun Zhao, Timothy Y Huang, Zhaoping Lu, Hong Luo, Dan Can, Huaxi Xu, Yun-wu Zhang, Xian Zhang. Appoptosin Mediates Lesions Induced by Oxidative Stress Through the JNK-FoxO1 Pathway. Front Aging Neurosci 11: 243, 2019.
Jiechao Zhou, Hei-Man Chow, Yan Liu, Di Wu, Meng Shi, Jieyin Li, Lei Wen，Yuehong Gao, Guimiao Chen, Kai Zhuang, Hui Lin, Guanyun Zhang, Wenting Xie, Huifang Li, Lige Leng, Mengdan Wang, Naizhen Zheng, Hao Sun, Yingjun Zhao, Yunwu Zhang, Maoqiang Xue, Timothy Y. Huang, Guojun Bu, Huaxi Xu, Zengqiang Yuan, Karl Herrup, Jie Zhang. CDK5-dependent BAG3 degradation modulates synaptic protein turnover in Alzheimer’s disease. Biol Psych 87: 756-769, 2019.
Lu-Lin Jiang, Bing Zhu, Yingjun Zhao, Xiaoguang Li, Tongfei Liu, Juan Pina-Crespo, Lisa Zhou, Wenxi Xu, Maria J Rodriguez, Haiyang Yu, Don W. Cleveland, John Ravits, Sandrine Da Cruz, Tao Long, Timothy Y. Huang, Huaxi Xu. Membralin deficiency dysregulates astrocytic glutamate homeostasis leading to ALS-like impairment. J Clin Invest 129: 3103-3120, 2019. PMID: 31112137, PMCID: PMC6668683.
Lige Leng, Kai Zhuang, Zeyue Liu, Changquan Huang, Yuehong Gao, Guimiao Chen, Hui Lin, Yu Hu, Di Wu, Meng Shi, Wenting Xie, Hao Sun, Zhicheng Shao, Huifang Li, Kunkun Zhang, Wei Mo, Timothy Y. Huang, Maoqiang Xue, Zengqiang Yuan, Xia Zhang, Guojun Bu, Huaxi Xu, Qi Xu, Jie Zhang. Menin deficiency leads to depressive-like behavior in mice by modulating astrocyte-mediated neuroinflammation. Neuron 100: 551-563, 2018. PMID: 30220511
Dongdong Zhao, Jian Meng, Yingjun Zhao, Yuanhui Huo, Yan Liu, Naizhen Zheng, Muxian Zhang, Yue Gao, Zhicai Chen, Hao Sun, Xiangyu Wang, Chuya Jing, Tongmei Zhang, Xian Zhang, Hong Luo, Xin Wang, Jie Zhang, Fa-rong Liu, Yanfang Li, Guojun Bu, Lei Wen, Timothy Y. Huang, Huaxi Xu, Yun-wu Zhang. RPS23RG1 is Required for Synaptic Integrity and Rescues Alzheimer’s Associated Cognitive Deficits. Biol Psych S0006-3223(18)31782-7, 2018. PMID: 30292394, PMCID: PMC6389446
Kai Zhuang, Changquan Huang, Lige Leng, Honghua Zheng, Yuehong Gao, Guimiao Chen, Zhilin Ji, Hao Sun, Yu Hu, Di Wu, Meng Shi, Huifang Li, Yingjun Zhao, Yunwu Zhang, Maoqiang Xue, Guojun Bu, Timothy Y. Huang, Huaxi Xu, and Jie Zhang. Neuron-Specific Menin Deletion Leads to Synaptic Dysfunction and Cognitive Impairment by Modulating p35 Expression. Cell Rep 24: 701-712, 2018. PMID: 30021166
Ying Du,Yingjun Zhao, Chuan Li, Qiuyang Zheng, Jing Tian, Zhuyi Li, Timothy Y. Huang, Wei Zhang, Huaxi Xu. Inhibition of PKCδ reduces amyloid-beta levels and reverses Alzheimer Disease phenotypes. J Exp Med 215: 1665-1677, 2018. PMID: 29739836
Yingjun Zhao, Xilin Wu, Xiaoguang Li, Lu-Lin Jiang, Xun Gui, Yan Liu, Yu Sun, Bing Zhu, Juan C. Piña-Crespo, Ningyan Zhang, Xiaochun Chen, Guojun Bu, Zhiqiang An, Timothy Y. Huang and Huaxi Xu. TREM2 is a receptor for β-amyloid and mediates microglial response to β-amyloid. Neuron 97: 1023-1031, 2018. PMID: 29518356
Bing Zhu, LuLin Jiang, Timothy Huang, Yingjun Zhao, Tongfei Liu, Yongwang Zhong, Xiaoguang Li, Alexandre Campos, Kenneth Pomeroy, Eliezer Masliah, Dongxian Zhang and Huaxi Xu. ER-associated degradation regulates Alzheimer’s amyloid pathology and memory function by modulating γ-secretase activity. Nat Commun 8: 1472, 2017. PMID: 29133892
Timothy Y. Huang*, Yingjun Zhao*, Lu-lin Jiang, Xiaoguang Li, Yan Liu, Yu Sun, Juan Pina-Crespo, Bing Zhu, Eliezer Masliah, Thomas E. Willnow, Elena B. Pasquale, Huaxi Xu. SORLA attenuates EphA4 signaling and inhibits β-amyloid-induced neurodegeneration. J Exp Med 214: 3669-3685, 2017. PMID: 29114064, PMCID: PMC5716044.
Yingjun Zhao, Xiaoguang Li, Timothy Huang, Muxian Zhang, Xin Wang, Yun-wu Zhang, Guojun Bu, Qi Wang, and Huaxi Xu. Intracellular trafficking of triggering receptor expressed on myeloid cells 2 (TREM2) is regulated by presenilin 1. Experimental & Molecular Medicine, 49: e405, 2017 PMID: 29611543.
Xin Wang, Ying Zhou, Jian Wang, I-Chu Tseng, Timothy Huang, Yingjun Zhao, Qiuyang Zheng, Yue Gao, Hong Luo, Xian Zhang, Guojun Bu, Wanjin Hong, and Huaxi Xu. SNX27 Deletion Causes Hydrocephalus through Impairing Ependymal Cell Differentiation and Ciliogenesis. J. Neurosci 36: 12586-12597, 2016. PMID: 27974614 , PMCID: PMC5157104
Timothy Y. Huang, Yingjun Zhao, Xiaoguang Li, Xin Wang, I-Chu Tseng, Robert Thompson, Shichun Tu, Thomas E. Willnow, Yun-wu Zhang, Huaxi Xu. SNX27 and SORLA interact to reduce amyloidogenic subcellular distribution and processing of amyloid precursor protein (APP). J Neurosci 36: 7996-8011, 2016. PMID: 27466343, PMCID: PMC4961782
Li Yan, Yaomin Chen, Wubo Li, Xiumei Huang, Hedieh Badie, Fan Jian, Timothy Huang, Yingjun Zhao, Stanley N. Cohen, Limin Li, Yun-wu Zhang, Huanmin Luo, Shichun Tu & Huaxi Xu. RPS23RG1 reduces Aβ oligomer induced synaptic and cognitive deficits. Sci Rep 6: 18668, 2016. PMCID: PMC4702092
Yingjun Zhao, I-Chu Tseng, Charles J. Heyser, Edward Rockenstein, Michael Mante, Anthony Adame, Qiuyang Zheng, Timothy Huang, Xin Wang, Pharhad E. Arslan, Paramita Chakrabarty, Chengbiao Wu, Guojun Bu, William C. Mobley, Yun-wu Zhang, Peter St. George-Hyslop, Eliezer Masliah, Paul Fraser, Huaxi Xu. Appoptosin-Mediated Caspase Cleavage of Tau Contributes to Progressive Supranuclear Palsy Pathogenesis. Neuron 87: 963-975, 2015. PMID: 26335643, PMCID: PMC4575284
