Sanford Burnham Prebys Medical Discovery Institute 10901 N. Torrey Pines Rd La Jolla CA 92037 USA
Alzheimer's disease research menu (4-Course Theme)
(1) SNX27/the retromer complex SNX27 is an endosomal trafficking factor that associates with a core retromer complex (Vps26/Vps29/Vps35) which recycles transmembrane targets from the endosome to the cell surface. The retromer complex is downregulated in AD... could SNX27 be neuroprotective?
(more about SNX27 here) _______
(2) SORLA SORLA is a large transmembrane trafficking factor that has been associated with AD onset, and has been shown to associate with the retromer complex. Increasing SORLA levels can protect neuronal function in AD mouse brain, and we were surprised to find how this potentially occurs.
(more about SORLA here) _______
(3) TREM2 TREM2 is an immune receptor in microglia; mutations in TREM2 have been shown to greatly increase AD risk. How TREM2 mutations can affect AD is currently a burning question.
(more about TREM2 here) _______
(4) Proteostasis The accumulation of toxic protein species is a fundamental etiological event in AD and other neurodegenerative disorders. We are fortunate to work with other talented teams to investigate how proteostatic mechanisms such as ATF6 and Siah1a may be affected in AD and other neurodegenerative disorders. (more about ATF6, Siah1a here)
Publication du Jour
A unique role for the fragrant, savory, and soluble, cleaved form of the SORLA protein in mediating neurite outgrowth in injured neurons through activation of EGFR, MAPK/ERK pathways. Compliments of Jessica Stupack.